RESUMEN
To highlight the transmission and major phylogenetic clades of Mycobacterium tuberculosis, a retrospective study was carried out at two health facilities in a small agro-industrial area in Sao Paulo, Brazil, that has a low tuberculosis incidence rate. IS6110-RFLP and spoligotyping were performed on the isolates, with the former revealing that 31.3% (35/112) of strains were clustered. Epidemiological links were found in 16 of the 35 clustered patients and were associated with transmission among patients living in public housing. Spoligotyping grouped 62.8% of the strains. The T genetic family predominated among the isolates. Of interest is that five strains had a pattern characteristic of African or Asian origin (ST535), and two others were of the rare localized type ST1888 (BRA, VEN). In addition, three new types--1889, 1890, and 1891--were identified. Spoligotyping showed that some ST may be circulating to or from Brazil, and RFLP revealed ongoing transmission in inadequately ventilated public-housing buildings. This may point to a failure in tuberculosis control policy.
Asunto(s)
Mycobacterium tuberculosis/clasificación , Mycobacterium tuberculosis/genética , Tuberculosis Pulmonar/epidemiología , Brasil/epidemiología , Elementos Transponibles de ADN , Femenino , Humanos , Incidencia , Masculino , Oligonucleótidos/análisis , Polimorfismo de Longitud del Fragmento de Restricción , Vivienda Popular , Tuberculosis Pulmonar/microbiologíaRESUMEN
This article will also be published in Portuguese in the Bol. Oficina Sanit. Panam. Vol. 114, No. 6, 1993
Asunto(s)
Gastroenteritis , Brotes de Enfermedades , Contaminación del Agua , BrasilRESUMEN
Publica-se este artigo no Bull. Pan Am. Health Organ. Vol. 27, No. 3, 1993
